Infection of mice by the respiratory route with Salmonella typhimurium
نویسندگان
چکیده
منابع مشابه
Immune response to infection with Salmonella typhimurium in mice.
Infection of mice with Salmonella typhimurium results in systemic infection and a disease similar to that seen in humans after infection with S. typhi. The innate immune system can restrict replication of S. typhimurium to a certain degree, but for effective control and eradication of bacteria, acquired immunity is essential. Salmonella infection induces the generation of specific CD4+ and CD8+...
متن کاملOral infection of mice with Salmonella enterica serovar Typhimurium causes meningitis and infection of the brain
BACKGROUND Salmonella meningitis is a rare and serious infection of the central nervous system following acute Salmonella enterica sepsis. For this pathogen, no appropriate model has been reported in which to examine infection kinetics and natural dissemination to the brain. METHODS Five mouse lines including C57BL/6, Balb/c, 129S6-Slc11a1tm1Mcg, 129S1/SvImJ, B6.129-Inpp5dtm1Rkh were used in ...
متن کاملThe role of macrophages in primary and secondary infection of mice with Salmonella typhimurium.
Elimination of macrophages with high-molecular dextran sulphate (DS) markedly impairs resistance of mice to primary infection with smooth, virulent strains of Salmonella typhimurium, whereas stimulation of this system by killed Bordetella pertussis organisms increases resistance. In infection with rough, avirulent strains of S. typhimurium the elimination of macrophages was not followed by an e...
متن کاملExperimental adaptation of Salmonella typhimurium to mice.
Experimental evolution is a powerful approach to study the dynamics and mechanisms of bacterial niche specialization. By serial passage in mice, we evolved 18 independent lineages of Salmonella typhimurium LT2 and examined the rate and extent of adaptation to a mainly reticuloendothelial host environment. Bacterial mutation rates and population sizes were varied by using wild-type and DNA repai...
متن کاملTreatment of experimental Salmonella typhimurium infection with mecillinam and ampicillin.
The activities of mecillinam and ampicillin, alone and in combination, were evaluated in mice infected with the LT-2 strain of Salmonella typhimurium. The minimal inhibitory concentrations of mecillinam and ampicillin for this strain were, respectively, 6.2 and 0.4 microgram/ml of culture medium. In vitro synergy was demonstrated. CF-1 mice inoculated intraperitoneally with 10(4) colony-forming...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Hygiene
سال: 1961
ISSN: 0022-1724
DOI: 10.1017/s0022172400038961